{"id":39625,"date":"2024-11-02T06:50:33","date_gmt":"2024-11-02T06:50:33","guid":{"rendered":"http:\/\/atmokpo.com\/w\/?p=39625"},"modified":"2024-11-26T06:41:13","modified_gmt":"2024-11-26T06:41:13","slug":"%ec%9d%98%eb%a3%8c-%eb%b0%8f-%eb%b0%94%ec%9d%b4%ec%98%a4-%eb%8d%b0%ec%9d%b4%ed%84%b0%ec%85%8b-tcga-the-cancer-genome-atlas-%ec%95%94-%ec%9c%a0%ec%a0%84%ec%b2%b4-%eb%b0%8f-%ec%9e%84%ec%83%81","status":"publish","type":"post","link":"https:\/\/atmokpo.com\/w\/39625\/","title":{"rendered":"\uc758\ub8cc \ubc0f \ubc14\uc774\uc624 \ub370\uc774\ud130\uc14b, TCGA (The Cancer Genome Atlas)  \uc554 \uc720\uc804\uccb4 \ubc0f \uc784\uc0c1 \ub370\uc774\ud130"},"content":{"rendered":"<p><body><\/p>\n<p>\n    \ud604\ub300\uc758\ub8cc\uc5d0\uc11c \ub370\uc774\ud130 \ubd84\uc11d\uc758 \uc911\uc694\uc131\uc774 \ub0a0\ub85c \uc99d\uac00\ud558\uace0 \uc788\ub294 \uac00\uc6b4\ub370, \ub525\ub7ec\ub2dd \ubc0f \uba38\uc2e0\ub7ec\ub2dd \uae30\uc220\uc744 \ud65c\uc6a9\ud558\uc5ec \uc758\ub8cc \ubc0f \ubc14\uc774\uc624 \ub370\uc774\ud130\ub97c \ucc98\ub9ac\ud558\ub294 \uac83\uc774 \uc911\uc694\ud574\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uae00\uc5d0\uc11c\ub294 TCGA(The Cancer Genome Atlas) \ub370\uc774\ud130\uc14b\uc5d0 \ub300\ud574 \uc2ec\ub3c4 \uc788\uac8c \ub2e4\ub8e8\uaca0\uc2b5\ub2c8\ub2e4. TCGA\ub294 \uc554 \uc5f0\uad6c\ub97c \uc704\ud55c \uae30\uc900 \ub370\uc774\ud130\uc14b\uc73c\ub85c, \uc720\uc804\uccb4 \ubc0f \uc784\uc0c1 \ub370\uc774\ud130\ub97c \ud3ec\ud568\ud558\uace0 \uc788\uc5b4 \uc5f0\uad6c\uc790\ub4e4\uc5d0\uac8c \uadc0\uc911\ud55c \uc790\uc6d0\uc785\ub2c8\ub2e4.\n<\/p>\n<h2>1. TCGA \uac1c\uc694<\/h2>\n<p>\n    TCGA\ub294 \ubbf8\uad6d \uad6d\ub9bd\uc554\uc5f0\uad6c\uc18c(National Cancer Institute, NCI)\uc640 \uad6d\ub9bd\uc778\uac04\uc720\uc804\uccb4\uc5f0\uad6c\uc18c(National Human Genome Research Institute, NHGRI)\uc758 \ud611\ub825\uc73c\ub85c \uc2dc\uc791\ub41c \ud504\ub85c\uc81d\ud2b8\ub85c, 2006\ub144\ubd80\ud130 \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4. TCGA\ub294 \ub2e4\uc591\ud55c \uc554 \uc720\ud615\uc5d0 \ub300\ud55c \uc720\uc804\uccb4 \ub370\uc774\ud130\uc640 \uc784\uc0c1 \uc815\ubcf4\ub97c \uc218\uc9d1\ud558\uc5ec \uc0dd\ubb3c\ud559\uc801 \uae30\ucd08\ub97c \uc774\ud574\ud558\uace0, \uc9c4\ub2e8 \ubc0f \uce58\ub8cc \ubc29\ubc95\uc744 \uac1c\ubc1c\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.\n<\/p>\n<h2>2. \ub370\uc774\ud130\uc758 \uad6c\uc131<\/h2>\n<p>\n    TCGA \ub370\uc774\ud130\ub294 \ud06c\uac8c \ub450 \uac00\uc9c0 \uce74\ud14c\uace0\ub9ac\ub85c \ub098\ub269\ub2c8\ub2e4:\n<\/p>\n<ul>\n<li><strong>\uc720\uc804\uccb4 \ub370\uc774\ud130:<\/strong> Datasets of nucleotide sequences that reveal variations in genes, such as mutations, copy number changes, DNA methylation, and RNA expression levels.<\/li>\n<li><strong>\uc784\uc0c1 \ub370\uc774\ud130:<\/strong> Information concerning patient demographics, tumor characteristics, treatments received, and outcomes.<\/li>\n<\/ul>\n<h3>2.1 \uc720\uc804\uccb4 \ub370\uc774\ud130<\/h3>\n<p>\n    \uc720\uc804\uccb4 \ub370\uc774\ud130\ub294 \ub2e4\uc591\ud55c \uae30\uc220\uc744 \ud1b5\ud574 \uc218\uc9d1\ub418\uba70, \uc554\uc758 \uc0dd\ubb3c\ud559\uc801 \ud2b9\uc131\uc744 \uc774\ud574\ud558\ub294 \ub370 \uc911\uc694\ud55c \ud1b5\ucc30\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc774 \ub370\uc774\ud130\ub294 \ub2e4\uc74c\uacfc \uac19\uc740 \uc815\ubcf4\ub97c \ud3ec\ud568\ud569\ub2c8\ub2e4:\n<\/p>\n<ul>\n<li>DNA \uc2dc\ud000\uc2f1 \ub370\uc774\ud130: \uc0d8\ud50c\uc758 \uc5fc\uae30\uc11c\uc5f4 \uc815\ubcf4\ub97c \ud3ec\ud568\ud569\ub2c8\ub2e4.<\/li>\n<li>\uc804\uc0ac\uccb4 \ub370\uc774\ud130: \uc720\uc804\uc790 \ud45c\ud604 \uc218\uc900\uc744 \ud3ec\ud568\ud558\uc5ec mRNA\uc758 \ubc1c\ud604\uc744 \uce21\uc815\ud569\ub2c8\ub2e4.<\/li>\n<li>\ud6c4\uc131 \uc720\uc804\ud559\uc801 \ub370\uc774\ud130: DNA \uba54\ud2f8\ud654 \ubc0f \ud788\uc2a4\ud1a4 \ubcc0\ud654\ub97c \ud1b5\ud574 \uc720\uc804\uc790 \uc870\uc808\uc744 \uc5f0\uad6c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<\/ul>\n<h3>2.2 \uc784\uc0c1 \ub370\uc774\ud130<\/h3>\n<p>\n    \uc784\uc0c1 \ub370\uc774\ud130\ub294 \ud658\uc790\uc758 \uc815\ubcf4\uc640 \uc554\uc5d0 \ub300\ud55c \uce58\ub8cc \uacb0\uacfc\ub97c \ub2f4\uace0 \uc788\uc73c\uba70, \uc774\ub7ec\ud55c \ub370\uc774\ud130\ub294 \uac01 \ud658\uc790\uc758 \uc0dd\uc874\uc728, \uce58\ub8cc \ubc18\uc751 \ubc0f \ubd80\uc791\uc6a9\uc744 \ubd84\uc11d\ud558\ub294 \ub370 \uc720\uc6a9\ud569\ub2c8\ub2e4. \uc8fc\uc694 \uc815\ubcf4\ub294 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4:\n<\/p>\n<ul>\n<li>\ud658\uc790 ID \ubc0f \uc778\uad6c\ud1b5\uacc4\ud559\uc801 \ud2b9\uc131 (\ub098\uc774, \uc131\ubcc4 \ub4f1)<\/li>\n<li>\uc554 \uc720\ud615 \ubc0f \ubcd1\uae30 (stage)<\/li>\n<li>\uce58\ub8cc \ubc29\ubc95 \ubc0f \uce58\ub8cc \uacb0\uacfc<\/li>\n<\/ul>\n<h2>3. TCGA \ub370\uc774\ud130\uc758 \uc911\uc694\uc131<\/h2>\n<p>\n    TCGA \ub370\uc774\ud130\uc14b\uc740 \uc554 \uc5f0\uad6c\uc5d0 \uc788\uc5b4\uc11c \ub9e4\uc6b0 \uc911\uc694\ud55c \uc790\uc6d0\uc785\ub2c8\ub2e4. \uc774 \ub370\uc774\ud130\uc14b\uc744 \ud1b5\ud574 \uc5f0\uad6c\uc790\ub4e4\uc740 \ub2e4\uc74c\uacfc \uac19\uc740 \ub2e4\uc591\ud55c \uc5f0\uad6c\ub97c \uc218\ud589\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4:\n<\/p>\n<ul>\n<li>\uc720\uc804\uc790 \ubcc0\ud615\uacfc \uc554 \ubc1c\uc0dd \uc0ac\uc774\uc758 \uc0c1\uad00\uad00\uacc4 \ubd84\uc11d<\/li>\n<li>\uc608\ud6c4 \uc778\uc790 \ud0d0\uc0c9: \uc5b4\ub5a4 \uc720\uc804\uc790\uac00 \ud2b9\uc815 \uc554\uc758 \uc0dd\uc874\uc728\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0 \uc5f0\uad6c<\/li>\n<li>\uc0c8\ub85c\uc6b4 \uc554 \uce58\ub8cc\ubc95 \uac1c\ubc1c: \ud2b9\uc815 \uc720\uc804\uc790 \ubcc0\ud615\uc5d0 \uae30\ubc18\ud55c \ud45c\uc801 \uce58\ub8cc\ubc95 \uac1c\ubc1c<\/li>\n<\/ul>\n<p>\n    \ub610\ud55c TCGA \ub370\uc774\ud130\ub294 \uba38\uc2e0\ub7ec\ub2dd \ubc0f \ub525\ub7ec\ub2dd \uc54c\uace0\ub9ac\uc998\uc758 \uad50\uc721\uc5d0 \uc0ac\uc6a9\ub420 \uc218 \uc788\uc5b4, \ub2e4\uc591\ud55c \uc608\uce21 \ubaa8\ub378\uacfc \uc9c4\ub2e8 \ub3c4\uad6c \uac1c\ubc1c\uc5d0 \uae30\uc5ec\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.\n<\/p>\n<h2>4. TCGA \ub370\uc774\ud130 \uc811\uadfc \ubc29\ubc95<\/h2>\n<p>\n    TCGA \ub370\uc774\ud130\uc5d0 \uc811\uadfc\ud558\ub294 \ubc29\ubc95\uc740 \uc5ec\ub7ec \uac00\uc9c0\uac00 \uc788\uc73c\uba70, \ub300\ubd80\ubd84\uc758 \ub370\uc774\ud130\ub294 \uacf5\uac1c\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \ub300\ud45c\uc801\uc778 \ub370\uc774\ud130 \uc811\uadfc \ubc29\ubc95\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4:\n<\/p>\n<ul>\n<li><strong>GDC (Genomic Data Commons):<\/strong> TCGA \ub370\uc774\ud130\ub97c \ud3ec\ud568\ud558\uc5ec \ub2e4\uc591\ud55c \uc720\uc804\uccb4 \ub370\uc774\ud130\ub97c \uc81c\uacf5\ud558\ub294 \ud50c\ub7ab\ud3fc\uc785\ub2c8\ub2e4. \uc720\uc800\ub294 GDC \ud3ec\ud138\uc744 \ud1b5\ud574 \ub370\uc774\ud130\ub97c \ud0d0\uc0c9\ud558\uace0 \ub2e4\uc6b4\ub85c\ub4dc\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<li><strong>cBioPortal:<\/strong> TCGA \ub370\uc774\ud130\ub97c \uc2dc\uac01\ud654\ud558\uace0 \ubd84\uc11d\ud560 \uc218 \uc788\ub294 \uc6f9 \uae30\ubc18 \ub3c4\uad6c\ub85c, \uc0ac\uc6a9\uc790\uac00 \uad00\uc2ec \uc788\ub294 \ud2b9\uc815 \uc720\uc804\uc790\ub098 \uc554 \uc720\ud615\uc744 \uc870\ud68c\ud558\uace0 \ubd84\uc11d\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<li><strong>TCGA \ub370\uc774\ud130\uc14b\uc758 \uacfc\ud559\uc801 \ub17c\ubb38:<\/strong> TCGA \uad00\ub828 \uc5f0\uad6c \uacb0\uacfc\uc640 \ub370\uc774\ud130 \uc0ac\uc6a9\uc744 \ub2e4\ub8ec \ub2e4\uc591\ud55c \uacfc\ud559\uc801 \ub17c\ubb38\ub4e4\uc774 \uacf5\uac1c\ub418\uc5b4 \uc788\uc5b4, \uc5f0\uad6c \uae30\ud68c\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/li>\n<\/ul>\n<h2>5. TCGA \uc0ac\ub840 \uc5f0\uad6c<\/h2>\n<p>\n    TCGA \ub370\uc774\ud130\uc14b\uc744 \ud65c\uc6a9\ud55c \uc5ec\ub7ec \uc5f0\uad6c \uc0ac\ub840\ub97c \ud1b5\ud574, \uc774 \ub370\uc774\ud130\uc14b\uc774 \uc5b4\ub5bb\uac8c \ud65c\uc6a9\ub418\uace0 \uc788\ub294\uc9c0 \uc0b4\ud3b4\ubcf4\uaca0\uc2b5\ub2c8\ub2e4.\n<\/p>\n<h3>5.1 \uc720\uc804\uc790 \ubcc0\ud615 \ubd84\uc11d<\/h3>\n<p>\n    \uc5f0\uad6c\uc790\ub4e4\uc740 TCGA \ub370\uc774\ud130\ub97c \uc0ac\uc6a9\ud574 \ud2b9\uc815 \uc554\uc5d0\uc11c \ud754\ud788 \ubc1c\uc0dd\ud558\ub294 \uc720\uc804\uc790 \ubcc0\ud615\uc744 \uc2dd\ubcc4\ud588\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc720\ubc29\uc554, \ud3d0\uc554, \ub300\uc7a5\uc554\uc5d0\uc11c \ubc1c\uacac\ub41c \uc8fc\uc694 \ubcc0\ud615\ub4e4\uc744 \ud1b5\ud574, \uc0c8\ub85c\uc6b4 \uc9c4\ub2e8 \ubc0f \uce58\ub8cc\ubc95 \uac1c\ubc1c\uc5d0 \uae30\uc5ec\ud558\uc600\uc2b5\ub2c8\ub2e4.\n<\/p>\n<h3>5.2 \uba38\uc2e0\ub7ec\ub2dd\uc744 \ud1b5\ud55c \uc608\ud6c4 \uc608\uce21<\/h3>\n<p>\n    TCGA \ub370\uc774\ud130\ub97c \uc774\uc6a9\ud558\uc5ec \uba38\uc2e0\ub7ec\ub2dd \ubaa8\ub378\uc744 \uac1c\ubc1c\ud558\uc5ec \ud658\uc790\uc758 \uc0dd\uc874\uc728\uc744 \uc608\uce21\ud558\ub294 \uc5f0\uad6c\uac00 \uc9c4\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc608\uce21 \ubaa8\ub378\uc740 \ud658\uc790 \ub9de\ucda4\ud615 \uce58\ub8cc \uc804\ub7b5\uc744 \uc138\uc6b0\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.\n<\/p>\n<h3>5.3 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95 \uac1c\ubc1c<\/h3>\n<p>\n    TCGA\uc758 \uc720\uc804\uccb4 \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud558\uc5ec \ud2b9\uc815 \uc720\uc804\uc790 \ubcc0\ud615\uc5d0 \ub300\ud55c \ud45c\uc801 \uce58\ub8cc\ubc95\uc774 \uc5f0\uad6c\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc554 \uce58\ub8cc\uc758 \ud601\uc2e0\uc801\uc778 \uc811\uadfc \ubc29\uc2dd\uc744 \uc81c\uacf5\ud558\uba70, \ud658\uc790\uc758 \uc554 \uc720\ud615 \ubc0f \uc720\uc804\uc790 \ubcc0\ud615\uc5d0 \ub9de\ucda4\ud615 \uce58\ub8cc\ub97c \uac00\ub2a5\ud558\uac8c \ud569\ub2c8\ub2e4.\n<\/p>\n<h2>6. \ub370\uc774\ud130 \uc0ac\uc6a9 \uc2dc \uc720\uc758\uc0ac\ud56d<\/h2>\n<p>\n    TCGA\uc640 \uac19\uc740 \ub300\uaddc\ubaa8 \ub370\uc774\ud130\uc14b\uc744 \uc0ac\uc6a9\ud560 \ub54c\ub294 \uba87 \uac00\uc9c0 \uc720\uc758\ud574\uc57c \ud560 \uc810\uc774 \uc788\uc2b5\ub2c8\ub2e4.\n<\/p>\n<ul>\n<li><strong>\uc724\ub9ac\uc801 \uace0\ub824:<\/strong> \ud658\uc790\uc758 \uac1c\uc778 \uc815\ubcf4 \ubc0f \uc758\ub8cc \uc815\ubcf4 \ubcf4\ud638\uac00 \uc911\uc694\ud569\ub2c8\ub2e4. \uc5f0\uad6c\uc790\ub294 \ud544\uc694\ud55c \uacbd\uc6b0 \uc724\ub9ac \uc704\uc6d0\ud68c\uc758 \uc2b9\uc778\uc744 \ubc1b\uc544\uc57c \ud569\ub2c8\ub2e4.<\/li>\n<li><strong>\ub370\uc774\ud130\uc758 \ud488\uc9c8:<\/strong> \ub370\uc774\ud130\uac00 \ucda9\ubd84\ud788 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294\uc9c0\ub97c \ud3c9\uac00\ud558\uace0, \uacb0\uce21\uce58\ub098 \uc774\uc0c1\uce58\ub97c \ucc98\ub9ac\ud574\uc57c \ud569\ub2c8\ub2e4.<\/li>\n<li><strong>\ub2e4\uc591\uc131 \uace0\ub824:<\/strong> \ub2e4\uc591\ud55c \uc5f0\uad6c \uacb0\uacfc\ub97c \ubcf4\uace0\ud558\uace0, \ud2b9\uc815 \uadf8\ub8f9\uc5d0 \ub300\ud574 \uc77c\ubc18\ud654\ud558\ub294 \ub370 \uc8fc\uc758\ud574\uc57c \ud569\ub2c8\ub2e4.<\/li>\n<\/ul>\n<h2>7. \uacb0\ub860<\/h2>\n<p>\n    TCGA\ub294 \uc554 \uc5f0\uad6c\uc5d0 \uc788\uc5b4 \ud544\uc218\uc801\uc778 \uc790\uc6d0\uc73c\ub85c, \uc720\uc804\uccb4 \ubc0f \uc784\uc0c1 \ub370\uc774\ud130\ub97c \ud1b5\ud574 \ub2e4\uc591\ud55c \uc5f0\uad6c \uae30\ud68c\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub370\uc774\ud130\uc14b\uc740 \ud604\ub300\uc758 \uba38\uc2e0\ub7ec\ub2dd \ubc0f \ub525\ub7ec\ub2dd \uae30\uc220\uc744 \ud1b5\ud574 \uc554 \ubc1c\uc0dd \uc6d0\uc778 \ubc0f \uce58\ub8cc\ubc95 \uac1c\ubc1c\uc744 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uae38\uc744 \uc5f4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc740 TCGA \ub370\uc774\ud130\ub97c \ud1b5\ud574 \uc554 \uc5f0\uad6c\uc758 \ud601\uc2e0\uc801\uc778 \ubc1c\uc804\uc744 \uc774\ub904\ub0bc \uc218 \uc788\uc73c\uba70, \uc774\ub97c \ud1b5\ud574 \uad81\uadf9\uc801\uc73c\ub85c \ud658\uc790\ub4e4\uc5d0\uac8c \ubcf4\ub2e4 \ub098\uc740 \uce58\ub8cc \uacb0\uacfc\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\uc744 \uac83\uc785\ub2c8\ub2e4.\n<\/p>\n<h2>8. \ucc38\uace0 \uc790\ub8cc<\/h2>\n<p>\n    TCGA \ub370\uc774\ud130\uc5d0 \ub300\ud55c \ub354 \uc790\uc138\ud55c \uc815\ubcf4\ub294 \ub2e4\uc74c \ub9c1\ud06c\ub97c \ud1b5\ud574 \uc811\uadfc\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4:\n<\/p>\n<ul>\n<li><a href=\"https:\/\/www.cancer.gov\/tcga\">TCGA \uacf5\uc2dd \uc6f9\uc0ac\uc774\ud2b8<\/a><\/li>\n<li><a href=\"https:\/\/gdc.cancer.gov\/\">Genomic Data Commons (GDC)<\/a><\/li>\n<li><a href=\"https:\/\/www.cbioportal.org\/\">cBioPortal for Cancer Genomics<\/a><\/li>\n<\/ul>\n<p><\/body><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud604\ub300\uc758\ub8cc\uc5d0\uc11c \ub370\uc774\ud130 \ubd84\uc11d\uc758 \uc911\uc694\uc131\uc774 \ub0a0\ub85c \uc99d\uac00\ud558\uace0 \uc788\ub294 \uac00\uc6b4\ub370, \ub525\ub7ec\ub2dd \ubc0f \uba38\uc2e0\ub7ec\ub2dd \uae30\uc220\uc744 \ud65c\uc6a9\ud558\uc5ec \uc758\ub8cc \ubc0f \ubc14\uc774\uc624 \ub370\uc774\ud130\ub97c \ucc98\ub9ac\ud558\ub294 \uac83\uc774 \uc911\uc694\ud574\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uae00\uc5d0\uc11c\ub294 TCGA(The Cancer Genome Atlas) \ub370\uc774\ud130\uc14b\uc5d0 \ub300\ud574 \uc2ec\ub3c4 \uc788\uac8c \ub2e4\ub8e8\uaca0\uc2b5\ub2c8\ub2e4. TCGA\ub294 \uc554 \uc5f0\uad6c\ub97c \uc704\ud55c \uae30\uc900 \ub370\uc774\ud130\uc14b\uc73c\ub85c, \uc720\uc804\uccb4 \ubc0f \uc784\uc0c1 \ub370\uc774\ud130\ub97c \ud3ec\ud568\ud558\uace0 \uc788\uc5b4 \uc5f0\uad6c\uc790\ub4e4\uc5d0\uac8c \uadc0\uc911\ud55c \uc790\uc6d0\uc785\ub2c8\ub2e4. 1. 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